The Prime Minister has missed the last two sessions while recovering from coronavirus, but will now finally return.
It comes on the same day the UK’s official death toll became the highest in Europe, at more than 32,000.
Replacing Jeremy Corbyn last month, Sir Keir has called for the PM to form a “national consensus” on easing restrictions.
The pair are expected to clash on the Government’s handling of the pandemic, with the PM being grilled over his plans for easing the lockdown.
Mr Johnson has not taken questions in the Commons since March 25, before Parliament broke early for Easter.
He was recovering at the Chequers country estate after being discharged from intensive care.
The PM is expected to unveil his “roadmap” of future steps on Sunday.